TRAIL gene 1595C/T polymorphisms contribute to the susceptibility and severity of intervertebral disc degeneration: a data synthesis

Qi-Ling Yuan,Yin-Gang Zhang,Yong-Song Cai,Liang Liu

doi:10.1186/s12891-017-1916-3

Abstract

BackgroundStudies have investigated the correlation between tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene polymorphisms and the susceptibility and severity of intervertebral disc degeneration (IDD), but the results were inconsistent. To evaluate the specific relationship, we performed a meta-analysis to clarify the controversies.MethodsFour databases were searched, and the pooled results were presented as odds ratios (ORs) with 95% confidence intervals (CIs).ResultsThree case-control studies from Han Chinese were included (565 cases and 427 controls). All the included studies reported TRAIL 1595C/T gene polymorphisms. The recessive model (CC vs. CT + TT) was the optimal model, which demonstrated a significant relationship between 1595C/T polymorphisms and increased IDD risk (OR = 2.18, 1.45 to 3.27, P = 0.000). No significant heterogeneity was found in the recessive model (I2 = 48.6%, P = 0.143). Patients with lower grade IDD had more genotypes or alleles including 1595TT genotype (grade II vs. grade III: OR = 2.12, 1.18 to 3.83, P = 0.012; grade III vs. grade IV: OR = 2.59, 1.29 to 5.22, P = 0.007) and 1595 T allele (grade II vs. grade III: OR = 1.91, 1.43 to 2.55, P = 0.000; grade II vs. grade IV: OR = 2.46, 0.94 to 1.76, P = 0.000).ConclusionsThere is a significant relationship between 1595C/T polymorphisms and the susceptibility and severity of IDD in Han Chinese. Patients with lower grade IDD had higher frequency of the 1595TT genotype and 1595 T allele.

Highlights

Studies have investigated the correlation between tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene polymorphisms and the susceptibility and severity of intervertebral disc degeneration (IDD), but the results were inconsistent
A total of 2 duplicates were excluded, and 179 additional records were excluded based on the titles or abstracts for reasons such as the presence of a disorder that was not related to IDD, no TRAIL genes were evaluated, or studies that used non-human subjects
Major findings Our meta-analysis revealed the differential distribution of genotype/allele frequencies of the TRAIL 1595C/T gene among different clinical grades of IDD patients in the Han Chinese population

Summary

Results

Characteristics of studies Our search strategy identified 198 potentially eligible records (Fig. 1). All the included studies reported TRAIL 1595C/T gene polymorphisms. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) was applied in all included studies. The metagen command in STATA was used to identify the optimal genetic model for TRAIL 1595C/T gene polymorphisms. M male, F female, SD standard deviation, IDD intervertebral disc degeneration, PCR-RFLP polymerase chain reaction–restriction fragment length polymorphism, MRI magnetic resonance imaging. Meta-analyses of disc degeneration grades among IDD patients with different 1595C/T genotypes and alleles are shown in.

Conclusions

Background

Methods

Discussion

Conclusion