Abstract
A new Erythrinan alkaloid ( 1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids ( 2– 7, 9) and an indole alkaloid ( 8). The structure of new compound ( 1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Erysotrine ( 4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.
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