Abstract
The use of medicinal plants as a fundamental component of the African traditional healthcare system is perhaps the oldest and the most assorted of all therapeutic systems. In many parts of rural Africa, traditional healers prescribing medicinal plants are the most easily accessible and affordable health resource available to the local community and at times the only therapy that subsists. Nonetheless, there is still a paucity of updated comprehensive compilation of promising medicinal plants from the African continent. The major focus of the present review is to provide an updated overview of 10 promising medicinal plants from the African biodiversity which have short- as well as long-term potential to be developed as future phytopharmaceuticals to treat and/or manage panoply of infectious and chronic conditions. In this endeavour, key scientific databases have been probed to investigate trends in the rapidly increasing number of scientific publications on African traditional medicinal plants. Within the framework of enhancing the significance of traditional African medicinal plants, aspects such as traditional use, phytochemical profile, in vitro, in vivo, and clinical studies and also future challenges pertaining to the use of these plants have been explored.
Highlights
Traditional medicine is the sum total of knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures that are used to maintain health, as well as to prevent, diagnose, improve, or treat physical and mental illnesses [1]
The aqueous extracts of M. charantia improved oral glucose tolerance test (OGTT) after 8 h in normal mice and reduced hyperglycaemia by 50% after 5 h in STZ diabetic mice
We recently reported that M. charantia fruit extracts have a direct impact on transport of glucose in vitro [99, 114,115,116,117]
Summary
Traditional medicine is the sum total of knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures that are used to maintain health, as well as to prevent, diagnose, improve, or treat physical and mental illnesses [1]. Traditional medicine that has been adopted by other populations (outside its indigenous culture) is often termed complementary or alternative medicine (CAM) [1, 2]. It is likely that the profound knowledge of herbal remedies in traditional cultures, developed through trial and error over many centuries, along with the most important cures was carefully passed on verbally from one generation to another. Modern allopathic medicine has its roots in this ancient medicine, and it is likely that many important new remedies will be developed and commercialized in the future from the African biodiversity, as it has been till by following the leads provided by traditional knowledge and experiences [2,3,4,5]
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