Abstract
Background Traditional Chinese medicine (TCM) for the treatment of female infertility remains ambiguous. The aim of the present case-control study was to examine the association between TCM treatment and successful pregnancy among infertile women. Methods This population-based case-control study included the data from 2,627 infertile women with successful pregnancy and 2,627 infertile women without successful pregnancy using datasets from the Longitudinal Health Insurance Database 2000 of the National Health Insurance Research Database during 2000–2010. The odds ratios (ORs) and 95% confidence intervals (CIs) for the relationship between TCM use and successful pregnancy in infertility women were estimated using logistic regression. Results Patients who received TCM treatment significantly increased in successful pregnancy (OR = 1.48; 95% CI = 1.31–1.66), compared with patients without TCM. Si-Wu-Tang (OR = 4.25; 95% CI = 2.18, 8.30), Gui-Zhi-Fu-Ling-Wan (OR = 3.27; 95% CI = 2.13, 5.02), and Jia-Wei-Xiao-Yao-San (OR = 3.17; 95% CI = 2.35, 4.28) were the TCM agents that were most strongly associated with successful pregnancy among infertile women. Conclusions Our study findings indicate that TCM is associated with higher likelihood of successful pregnancy in infertile women, which is worthy of further investigation by randomized control trial.
Highlights
Infertility is an integral part of reproductive health and a priority global health issue. is condition is a critical problem that has to be solved by many countries with low birth rates
A crosssectional study of 8,766 new onset cases of female infertility reported the prevalence and associated factors of Traditional Chinese medicine (TCM) use, as well as the top 10 Chinese herbal product (CHP) formulas for female infertility [11]. These studies did not explore the specific effect of TCM treatment on infertile outcomes. us, the present study was aimed to examine the association between TCM treatment with successful pregnancy among infertile women using population-based case-control study with matching approach to reduce the confounding effects through assembling a sample in which potential confounding factors are balanced between TCM and non-TCM groups
Is study used the Longitudinal Health Insurance Database 2000 (LHID2000) of National Health Insurance Research Database (NHIRD). e LHID2000 of NHIRD sample and the entire population of NHIRD are similar in terms of age and sex distributions. e LHID2000 of NHIRD contains all outpatient and inpatient claim data of one million beneficiaries who were randomly sampled for 23 million enrollees in the National Health Insurance (NHI)
Summary
Infertility is an integral part of reproductive health and a priority global health issue. is condition is a critical problem that has to be solved by many countries with low birth rates. A crosssectional study of 8,766 new onset cases of female infertility reported the prevalence and associated factors of TCM use, as well as the top 10 Chinese herbal product (CHP) formulas for female infertility [11]. These studies did not explore the specific effect of TCM treatment on infertile outcomes. Us, the present study was aimed to examine the association between TCM treatment with successful pregnancy among infertile women using population-based case-control study with matching approach to reduce the confounding effects through assembling a sample in which potential confounding factors are balanced between TCM and non-TCM groups These studies did not explore the specific effect of TCM treatment on infertile outcomes. us, the present study was aimed to examine the association between TCM treatment with successful pregnancy among infertile women using population-based case-control study with matching approach to reduce the confounding effects through assembling a sample in which potential confounding factors are balanced between TCM and non-TCM groups
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