Abstract
Angelicae Pubescentis Radix (APR) is a widely used antirheumatic Chinese medicinal herb known as “Duhuo” in China. It has the effects of dispelling wind and removing dampness, diffusing impediment, and relieving pain, and is mainly indicated for rheumatic arthritis with pain in the lower back and knees, and headache. To the best of our knowledge, an attempt is made to provide an up-to-date review on these aspects based on published materials, including ancient and modern books; Master's and doctoral theses; monographs on medicinal plants; the pharmacopoeia of different countries, websites for publication of patent and electronic databases, such as SCI finder, PubMed, Web of Science, ACS, Science Direct, Wiley, Springer, Taylor, CNKI, and Google Scholar. APR, which has a good clinical effect, has been used for traditional Chinese medicine more than 2000 years. Since 1957, a variety of chemical constituents have been reported from the medicinal plants of this herb, mostly coumarins and volatile oil. In the past 30 years, numerous studies have shown that the extracts and compounds isolated from APR showed effective analgesic and anti-inflammatory actions, also showing well effects on central nervous system, effects on cardiovascular system and deworming activity. In addition, we also present and discuss the botany, traditional medicinal use, pharmacokinetics, toxicity, quality control, future trends and prospects of APR. All this information suggest that future research of APR should be supplemented in the area of pharmacology and toxicology to provide further insight on the clinical use and quality control.
Highlights
Angelicae Pubescentis Radix has been used as herbal medicine extensively since ancient times in Asian countries, including China, Korea and Japan
To assess the brain distributions and blood-brain barrier permeabilities of Angelicae Pubescentis Radix (APR), a UPLC-MS/MS method was applied to the simultaneous determinations of the main coumarins in the rat cerebrospinal fluid (CSF) and brain after oral administration of APR extract (4 g/kg), including psoralen (51), xanthotoxin (57), bergapten (52), isoimperatorin (55), columbianetin (43), columbianetin acetate (41), columbianadin (40), oxypeucedanin hydrate (56), angelol B (4), osthole (17), meranzin hydrate (20), and nodakenetin (69)
A significant breakthrough has been made in the last several decades in the areas of phytochemistry and pharmacology of APR
Summary
Angelicae Pubescentis Radix (equivalent to Angelica Pubescens Root, known as “Duhuo” in China, “Dokwhal” in Korea, “Dokkatsu” in Japan) has been used as herbal medicine extensively since ancient times in Asian countries, including China, Korea and Japan. Rheumatic arthralgia is the professional description of TCM syndrome, and includes clinical symptoms such as muscle and joint pain, joint deformities, and dysfunction, with resulting exhaustion and lack of strength These symptoms are common in rheumatic diseases such as rheumatism and rheumatoid arthritis (RA), with modern medicine ascribing them to an immune deficiency (Wang et al, 2009). From the Chinese Pharmacopoeia (version 1977), Angelicae Pubescentis Radix (APR) is the dried roots of Angelica biserrata (R.H.Shan & C.Q.Yuan) C.Q.Yuan & R.H.Shan A. pubescens, which used to be a medicinal plant for APR in China, is mainly produced in Japan and is used medically in that country at present (Zhengkang, 2006; Rao et al, 1994).
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