Abstract
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, characterized clinically by insidious onset of memory and cognition impairment, emergence of psychiatric symptoms and behavioral disorder, and impairment of activities of daily living (ADL). Traditional Chinese medicine (TCM) is practiced in the Chinese health care system for more than 2,000 years. In recent years, scientists have isolated many novel compounds from herbs, some of which improve dementia with fewer side effects than conventional drugs and are regarded as potential anti-AD drugs. In this review, we summarize the latest research progress on TCM showing their possible role of treatment of AD and other demented diseases and possible pharmacological actions.
Highlights
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, characterized clinically by insidious onset of memory and cognition impairment, emergence of psychiatric symptoms and behavioral disorder, and loss of activities of daily living (ADL)
Another study indicates that Huperzine A (HupA) treatment can significantly ameliorate the loss of dendritic spine density and synaptotagmin levels in the brain of Amyloid precursor (APP)/PS1 transgenic mice, and this neuroprotection was associated with reduced amyloid plaque burden and oligomeric betaamyloid (Abeta) levels in the cortex and hippocampus [4]
We found that curcumin suppressed activated astroglia induced by Abeta and it might act as a PPARgamma agonist to inhibit the inflammation in Abeta-treated astrocytes [24]
Summary
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, characterized clinically by insidious onset of memory and cognition impairment, emergence of psychiatric symptoms and behavioral disorder, and loss of activities of daily living (ADL). Another study indicates that HupA treatment can significantly ameliorate the loss of dendritic spine density and synaptotagmin levels in the brain of APP/PS1 transgenic mice, and this neuroprotection was associated with reduced amyloid plaque burden and oligomeric betaamyloid (Abeta) levels in the cortex and hippocampus [4]. HupA can improve triple transgenic mice (3xTg-AD) learning and memory in the Morris water maze and some indicators of emotionality without inducing important adverse effects.
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