Abstract
Introduction: Benign Prostatic Hypertrophy (BPH) and Lower Urinary Tract Symptoms (LUTS) frequently affect the male population after the age of 50. Moreover, it is well known that there is a correlation of these symptoms with Erectile Dysfunction (ED) that can reach a frequency of roughly 52% in men aged between 40 and 70 years old. In this study, we aimed at evaluating the effect of a new natural compound “Tradamixina TP” (composed of 80 mg of the algae Ecklonia Bicyclis, 100 mg of Tribulus terrestris and 100 mg of Chitosan Water-soluble oligosaccharide 320 mg of Serenoa repens) in the improvement of Lower Urinary Tract Symptoms (LUTS). Materials & Methods: One-hundred patients with an average age of 64 years old and who were not taking any medication or phytotherapy for prostatic hypertrophy or erectile dysfunction were recruited in the study. All participants were subjected to serum prostate antigen (PSA) and uroflowmetry measuring maximal urine flow/sec (Qmax), at baseline and after 12 weeks. In addition, patients were asked to take the Tradamixina TP for 3 months and to complete at the beginning and end of the treatment the following questionnaires: 1) the IPSS investigating the level of LUTS, and 2) the IIEF-15 investigating the erectile dysfunction. Results: After the treatment, the IPSS scores were lower than those before the treatment. Moreover, a significant effect was found for the IIEF erectile subdomain with scores that were significantly higher at 12 weeks than at baseline. A similar result was found for the IIEF overall subdomain. A decrease of total serum PSA was also observed. Conclusions: After 3 months of daily treatment, the new compound “Tradamixina TP” improved patients’ sexual function, LUTS and led also to a decrease in serum PSA levels.
Highlights
Benign Prostatic Hypertrophy (BPH) and Lower Urinary Tract Symptoms (LUTS) frequently affect the male population after the age of 50
It is well known that there is a correlation of these symptoms with Erectile Dysfunction (ED) that can reach a frequency of roughly 52% in men aged between 40 and 70 years old
We aimed at evaluating the effect of a new natural compound “Tradamixina TP” in the improvement of Lower Urinary Tract Symptoms (LUTS)
Summary
Lower Urinary Tract Symptoms (LUTS) are extremely common in men and increase with age [1]. An early medical intervention can help to delay the onset of the symptoms In this view, a treatment based on the use of Serenoa repens can have a positive effect on LUTS. Gacci and co-workers [17] have identified four pathogenetic theories behind ED/LUTS: A reduced NOS-NO signal; the theory of autonomic hyperactivity; the activation of Rho-kinase/endothelin and Pelvic atherosclerosis These theories, together or separately, can lead to dysfunctions at the level of the prostate, corpora cavernosa, urethra and bladder due to alterations of the nerve tissue and endothelium, the altered mechanism of muscle relaxation/contractility, and the reduced blood flow with consequent tissue damage, caused by hypoxia [17]. A new natural compound called “Tradamixina TP” (composed by algae Ecklonia bicyclis, Tribulus terrestris and Chitosan Water-soluble oligosaccharide, Serenoa repens) showed a general improvement of the sexual activity [18]. Patients were asked to take the Compound for 3 months and to complete, at the baseline and after 12 weeks, two questionnaires: The International Prostate Symptom Score (IPSS) investigating the level of LUTS; and b) the International Index Erectile Function (IIEF-15) investigating the erectile dysfunction through IIEF erectile, IIEF sexual, IIEF orgasmic, IIEF intercourse, and IIEF overall subdomains
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