Abstract

Previous studies have shown white matter compromise in children and adults with autism spectrum disorder (ASD), which may relate to reduced connectivity and impaired function in distributed networks. However, tract-specific evidence remains limited in ASD. We applied tract-based spatial statistics (TBSS; Smith et al., 2006) for an unbiased whole-brain quantitative estimation of the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the white matter tracts in children with ASD.

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