Abstract
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which has become a global concern with outbreaks in Asia, Africa, Europe and, recently, the Americas. It causes fever, myalgia and debilitating joint pain in infected patients, which in some cases can lead to severe arthritis or encephalitis. Despite extensive structural and molecular studies on CHIKV and other alphaviruses, there is still no direct, structural information on the conformational states that CHIKV undergoes during membrane fusion to release its genome into the host cell.
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