Abstract
Although the structural analysis of transcription has attained atomic resolution, techniques to manipulate single molecules involved in transcription have lagged behind. A recent paper in Nature by Abbondanzieri et al. (2005) closes this gap. This study finds that individual molecules of bacterial RNA polymerase move in single base-pair steps and concludes that RNA polymerase acts as a Brownian ratchet that is driven forward by the binding of incoming nucleoside triphosphates.
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