Abstract
Cancer Very few screening tests have increased the survival of individuals diagnosed with cancer. In a Perspective, Pashayan and Pharoah discuss the importance of understanding tumor growth dynamics, especially when metastases are seeded from the primary tumor. Metastasis is the major cause of mortality from cancer, so the ability to detect tumors before metastases arise is an important challenge. In particular, many tests based on imaging can only detect tumors of a certain size and others cannot discriminate which will progress, potentially causing harm. It is important to develop screening tests that can account for growth dynamics to identify individuals with tumors that are most likely to spread and cause mortality. Science , this issue p. [589][1] [1]: /lookup/doi/10.1126/science.aaz2078
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