Abstract
Background: TGF-β is the central pro-fibrogenic cytokine in the liver. In hepatocytes, cell death by apoptosis, growth arrest by cellular senescence or contribution towards healing by epithelial-mesenchymal transition are possible outcomes. We speculate that genetic differences underlying differences in response to TGF-β signalling may be involved in predisposition to fibrosis or hepatocellular carcinoma.
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