Abstract
During clathrin-mediated endocytosis (CME), receptors and their cargo are internalized, a required step in signalling cascades, receptor recycling, and entry of viruses and other small particles into the cell. It is commonly assumed that most engineered, drug-loaded vesicles enter the cell via CME, and many are conjugated with ligands to receptors that are targets of CME. In parallel, live-cell microscopy has been used to study the growth and development of endocytic pits, revealing their molecular-level mechanisms of assembly and detailed dynamics.
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