Abstract
Tracing SARS-Coronavirus Variant with Large Genomic Deletion
Highlights
AY274119) (3), are characterized by the deletion of a 29-nucleotide segment upstream of the nucleocapsid (N) gene domain when compared with the viral strains isolated from the earliest human severe acute respiratory syndrome (SARS) patients (2) or from nonhuman mammalian hosts (4)
Towards the end of the epidemic, a variant of the SARSCoV with a deletion of 386 nt flanking the 29-nt site was first demonstrated by complete genomic sequencing in 2 patients in Hong Kong
The deletion results in the disruption of a putative open reading frame, orf 9, while eliminating orfs 10 and 11. This deletion variant was first isolated from 2 SARS patients with disease onset in mid-May 2003
Summary
Consensus document on the epidemiology of severe acute respiratory syndrome (SARS). Address for correspondence: David Koh, Department of Community, Occupational and Family Medicine, Faculty of Medicine (MD3), National University of Singapore, 16 Medical Drive, Singapore 117597; fax: 65-6-7791489; email: cofkohd@nus.edu.sg To the Editor: Severe acute respiratory syndrome (SARS) has been a global public health issue (1).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
