Abstract
Trace amine-associated receptors (TAAR) have been an elusive species of G protein-coupled receptors (GPCR), so far, mainly because of their suboptimal expression in heterologous cell systems. Little connection could be established between the namegiving low physiological concentrations of their putative amine agonists, and their tissue-specific biological function. At the same time, there is growing evidence that suggests ectopic expression of certain TAAR, beyond their supposed typical tissue expression as olfactory receptors in the olfactory epithelium, at least in mice. Two recent publications now shed light on the potent activation by specific amines of certain TAAR in different primary cells: in olfactory sensory neurons (OSN) of the main olfactory epithelium (MOE) of mice, and, unexpectedly, in human peripheral blood leukocytes.
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