Tracheal intubating conditions in elderly patients when train-of-four count is zero after rocuronium 0.6 or 0.9mg/kg. A secondary analysis.

Abstract

The neuromuscular blocking agent rocuronium can be administered to facilitate tracheal intubation. We hypothesized that rocuronium 0.9mg/kg provided a larger proportion of patients with vocal cords in abducted position compared to rocuronium 0.6mg/kg at train-of-four (TOF) 0. This secondary analysis was based on 52 elderly surgical patients of which 36 patients received rocuronium 0.6mg/kg and 16 patients received rocuronium 0.9mg/kg. Neuromuscular block was monitored with acceleromyography with TOF stimulation at the ulnar nerve. The primary outcome was the proportion of patients with vocal cords in abducted position at TOF 0. Secondary outcomes were intubating conditions evaluated by the Fuchs-Buder scale, the Intubating Difficulty Score (IDS), onset time, and duration of action of rocuronium. At TOF 0, a significantly larger proportion of patients had vocal cords in abducted position in the rocuronium 0.9mg/kg group (81%) compared with the rocuronium 0.6mg/kg group (53%); difference (%) 28, 95% Cl 3-53, P = 0.05. Excellent intubating conditions (Fuchs-Buder) were more common in the rocuronium 0.9mg/kg group (62.5%); difference (%) 32.5, 95% Cl 4-61), P = 0.03. No significant difference was found in IDS or onset time of rocuronium (difference 19s, 95% Cl: -5-43). Duration of action was significantly longer (difference 29min, 95% Cl: 10-47) in the 0.9mg/kg group. The proportion of patients with vocal cords in abducted position was significantly larger after rocuronium 0.9mg/kg compared to rocuronium 0.6mg/kg at TOF 0 monitored at the ulnar nerve.