Abstract
The first records of smallpox and rabies date back thousands of years and foot-and-mouth disease in cattle was described in the 16th century. These diseases stood out by their distinct signs, dramatic way of transmission from rabid dogs to humans, and sudden appearance in cattle herds. By contrast, infectious diseases that show variable signs and affect few individuals were identified only much later. Bovine viral diarrhea (BVD), endemic in cattle worldwide, was first described in 1946, together with the eponymous RNA virus as its cause. There is general agreement that BVD was not newly emerging at that time, but its history remains unknown. A search for associations between the nucleotide sequences of over 7,000 BVD viral strains obtained during a national campaign to eradicate BVD and features common to the hosts of these strains enabled us to trace back in time the presence of BVD in the Swiss cattle population. We found that animals of the two major traditional cattle breeds, Fleckvieh and Swiss Brown, were infected with strains of only four different subgenotypes of BVDV-1. The history of these cattle breeds and the events that determined the current distribution of the two populations are well documented. Specifically, Fleckvieh originates from the Bernese and Swiss Brown from the central Alps. The spread to their current geographic distribution was determined by historic events during a major expansion of the Swiss Confederation during the 15th and 16th centuries. The association of the two cattle populations with different BVD viral subgenotypes may have been preserved by a lack of cattle imports, trade barriers within the country, and unique virus-host interactions. The congruent traces of history in the distribution of the two cattle breeds and distinct viral subgenotypes suggests that BVD may have been endemic in Switzerland for at least 600 years.
Highlights
Certain infectious diseases have been known for hundreds or even thousands of years
We found that animals of the two major traditional cattle breeds, Fleckvieh and Swiss Brown, were infected with strains of only four different subgenotypes of bovine virus diarrhea virus-1 (BVDV-1)
Since most animals acquire the infection from a PI herd mate, previous successful Bovine viral diarrhea (BVD) eradication programs had targeted the search for PI animals to herds with a high percentage of animals seropositive to BVD virus [27, 28]
Summary
Certain infectious diseases have been known for hundreds or even thousands of years. Examples include smallpox [1], rabies [2] and foot-and-mouth disease [3]. The first two stood out because of the sudden appearance and typical disease signs, whilst rabies was known as a deadly disease of humans that had been bitten by a rabid dog [2]. Understanding and fighting such diseases started the eras of immunology and microbiology in the 18th and 19th centuries. It includes two mutually exclusive types of infection, acute-transient when acquired postnatally and persistent when initiated in utero. Due to a high level of herd immunity, most animals are protected due to a previous transient infection, and only few in a herd will show disease signs at the same time [10, 11]
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