Traceless Solid Phase Synthesis with Polystyrene-Bound Tellurium and in Comparison with Polystyrene-Bound Selenium

Abstract

A novel traceless linking strategy by use of polystyrene-bound tellurium is described. The application of the tellurium linker is demonstrated by the solid phase synthesis of a small library of single alkyl aryl ethers containing two points of diversity. Polystyrene-bound tellurium and polystyrene-bound selenium are compared by their cleavage performance under radical conditions (homolysis) at different temperatures. In addition, polystyrene-bound substrates were analysed by the use of high-resolution magic angle spinning (HR-MAS) NMR spectroscopy.