Abstract
To ascertain whether calcium in drinking water inhibited accumulation of several trace metals in tissues, 40 Long-Evans weanling rats were separated as to sex and into groups, half receiving 200 ppm calcium. The diet, of rye, skim milk, and corn oil, was high in calcium. The water contained: (ppm) chromium, 2; manganese, 10; nickel, 5; copper, 5; zinc, 50; cadmium, 5; and lead, 5. At 400 to 533 days of age tissues were analyzed for these trace metals. No significant effect of calcium on mean concentrations in 5 organs was found. Renal cadmium, copper and zinc levels were highly correlated. The incidence of hypertension was partly suppressed in female rats rceiving calcium in drinking water. Hypertensive animals of both sexes had more extractable aortic lipids than did normotensive rats. Serum cholesterol levels were unaffected. Apparently calcium in drinking water, comparable to that in “hard” potable water did not affect the deposition in tissues of trace metals contained in the water.
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