Abstract
Fifty specimens of synovial fluid from patients with rheumatoid arthritis and an equal number of specimens from cadavers who died with no evidence of connective tissue disease, were analyzed by emission spectrometry for 14 different trace metals. One hundred and five specimens of blood serum from patients with rheumatoid arthritis, and an equal number of specimens from normal volunteers were similarly analyzed. In blood serum from patients with rheumatoid arthritis, the mean concentrations of copper, barium, cesium, manganese, tin and molybdenum were high; iron, zinc and lead were low; and aluminium, nickel, strontium, chromium and cadmium were normal. In synovial fluid from patients with rheumatoid arthritis, the mean concentrations of copper, iron and zinc were high; aluminum, barium, tin, strontium and cadmium were low; and manganese, nickel, cesium, chromium, lead and molybdenum were normal.
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