Trace determination of shiomarin using a hanging copper/amalgam drop electrode

Abstract

The electrochemical behavior of shiomarin (moxalactam; latamoxef sodium) was investigated at hanging copper/amalgam drop electrode (HCADE) in HCl–KCl solution (pH 1.1). It was found that shiomarin can form complex with Cu(II) and can be adsorbed at the electrode surface. The coordination number is 1 and the number of transfer electron involved in the reaction is 2. The peak current of the complex related to the concentration of shiomarin and was used to determine trace amounts of shiomarin in solution. The linear range of determination is from 1.0×10 −9 to 8.0×10 −5 M using differential pulse adsorptive cathodic stripping voltammetry (DPAdCSV). The detection limit is about 4.0×10 −10 M ( t a=70 s, S/N=3). The method was also applied to the determination of shiomarin in injection powder and urine sample with satisfactory results.