TRACE CONCENTRATIONS OF ORGANOCHLORINE COMPOUNDS IN BIOLOGICAL LIQUIDS OF THE RUSSIAN FAR EAST RESIDENTS

Abstract

The aim. The problem of accumulation of organochlorine compounds (OCPs) in the human body is relevant, because these substances have potential teratogenic, carcinogenic, hormonal, neurological and immunological properties. Thus, the purpose of the work is to identify trace organochlorine compounds (a-, ß-, y-hexachlorocyclohexane (HCH), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethane, dichlorodiphenyldichlorethylene (DDE)) in the blood and urine of the residents of the south of the Russian Far East. Methods. The urine and blood of residents of the south of the Russian Far Eastern region were examined by gas chromatography-mass spectrometry to study the content of OCPs trace concentrations. Results: a- and y-isomers of hexachlorocyclohexane (HCH), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichlorethylene (DDE) were detected in the urine. Only ß-HCH in the blood was detected. Conclusions. The spectrum of basic OCPs in the urine indicates the possibility of its excretion by the body; however, the detection in the blood of only ß-HCH indicates a longer retention of the latter as the most stable isomer. A comparative evaluation of the obtained results with the data of other authors showed that the detected concentrations of cholesterol in the blood of residents of the Far East were lower than in typical agricultural countries and were found in no more than 30 % of the sample.