Tpeak-Tend interval as a new risk factor for arrhythmic event in patient with Brugada syndrome

Abstract

Objective To evaluate Tpeak-Tend(Tp-e) interval in surface standard ECG as a new risk factor for arrhythmic event in patient with Brugada syndrome. Methods 23 male patients with Brugada syndrome and 20 male patients with paroxysmal supraventricular tachycardia(PSVT) as the control group were investigated in this study. Tp-e interval in surface standard ECG was compared between BrS and PSVT patients. Results Tp-e interval in BrS patients was significantly longer than that in PSVT patients (109.57 ± 2.86 ms vs. 88.50 ± 3.08ms, P < 0.05). There was significant difference in Tp-e interval between 16 BrS patients with arrhythmic events (including syncope, clinical ventricular fibrillation [VF] and programmed electrical stimulation [PES]-induced VF) and 7 BrS patients without arrhythmic events and PSVT patients(118.12 ± 0.40ms vs. 90.00 ± 5.27ms, P < 0.05; 118.12 ± 0.40ms vs. 88.50 ± 3.08ms, P <0.05). However, Tp-e interval was similar in BrS patients without arrhythmic events and PSVT patients (90.00 ± 5.27ms vs. 88.50 ± 3.08ms, P > 0.05). Conclusion The prolongation of Tp-e interval could serve as a new noninvasive event predictor for arrhyth- mic events in patients with Brugada syndrome.