TparvaDB: a database to support Theileria parva vaccine development

Paul Visendi ,Wallace Bulimo ,James O Ochanda ,Wanjiku Ng'ang'a ,Richard P Bishop ,Etienne P De Villiers

doi:10.1093/database/bar015

Abstract

We describe the development of TparvaDB, a comprehensive resource to facilitate research towards development of an East Coast fever vaccine, by providing an integrated user-friendly database of all genome and related data currently available for Theileria parva. TparvaDB is based on the Generic Model Organism Database (GMOD) platform. It contains a complete reference genome sequence, Expressed Sequence Tags (ESTs), Massively Parallel Signature Sequencing (MPSS) expression tag data and related information from both public and private repositories. The Artemis annotation workbench provides online annotation functionality. TparvaDB represents a resource that will underpin and promote ongoing East Coast fever vaccine development and biological research.Database URL: http://tparvadb.ilri.cgiar.org

Highlights

Theileria parva is a tick-transmitted haemoprotozoan parasite that causes an acute and often fatal disease of cattle, East Coast fever (ECF) (1)
ECF severely constrains the livelihoods of poor livestock-keepers in sub-Saharan Africa
The completion of the genome sequence of T. parva Muguga (3) represents an important milestone in research on the parasite biology, and has contributed to the identification of candidate schizont antigens for vaccine development targeting this stage of the parasite (4)

Summary

Original article

Paul Visendi[1], Wanjiku Ng’ang’a2, Wallace Bulimo[3], Richard Bishop[4], James Ochanda[1] and Etienne P. de Villiers4,*. We describe the development of TparvaDB, a comprehensive resource to facilitate research towards development of an East Coast fever vaccine, by providing an integrated user-friendly database of all genome and related data currently available for Theileria parva. TparvaDB is based on the Generic Model Organism Database (GMOD) platform. It contains a complete reference genome sequence, Expressed Sequence Tags (ESTs), Massively Parallel Signature Sequencing (MPSS) expression tag data and related information from both public and private repositories. The Artemis annotation workbench provides online annotation functionality. TparvaDB represents a resource that will underpin and promote ongoing East Coast fever vaccine development and biological research.

Introduction

TparvaDB architecture

Chromosome Gene model Change