Abstract
Steroids are nowadays routinely used as a long-term treatment in Duchenne muscular dystrophy (DMD). Their effects on body composition were assessed using Dual X-ray absorptiometry. The study followed over two years 29 genetically confirmed DMD patients: 21 in the steroid-treated group and 8 in the steroid-naive group. After two years of steroid treatment, the lean tissue mass values increased significantly ( p p =0.94) in comparison with the initial visit. In the steroid-naive patients, there were no significant increases in the lean tissue mass but deterioration in body composition confirmed by a significant increases in the percentage of body fat mass. Besides, significant negative correlations were found between the percentage of body fat mass and the MFM total score ( R =−0.79, n =76, p
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