Abstract
BackgroundDrawing integrated conclusions from diverse source data requires synthesis across multiple types of information. The ToxPi (Toxicological Prioritization Index) is an analytical framework that was developed to enable integration of multiple sources of evidence by transforming data into integrated, visual profiles. Methodological improvements have advanced ToxPi and expanded its applicability, necessitating a new, consolidated software platform to provide functionality, while preserving flexibility for future updates.ResultsWe detail the implementation of a new graphical user interface for ToxPi (Toxicological Prioritization Index) that provides interactive visualization, analysis, reporting, and portability. The interface is deployed as a stand-alone, platform-independent Java application, with a modular design to accommodate inclusion of future analytics. The new ToxPi interface introduces several features, from flexible data import formats (including legacy formats that permit backward compatibility) to similarity-based clustering to options for high-resolution graphical output.ConclusionsWe present the new ToxPi interface for dynamic exploration, visualization, and sharing of integrated data models. The ToxPi interface is freely-available as a single compressed download that includes the main Java executable, all libraries, example data files, and a complete user manual from http://toxpi.org.
Highlights
Drawing integrated conclusions from diverse source data requires synthesis across multiple types of information
As a result of this transparency and accessibility, Toxicological Prioritization Index (ToxPi) has been featured in reports and Marvel et al BMC Bioinformatics (2018) 19:80 monographs by the U.S National Academy of Sciences [8,9,10], the World Health Organization’s International Agency for Research on Cancer [11,12,13], and as part of the toolkit used by the U.S Environmental Protection Agency for a number of data visualization dashboards [14]
Selected sets or results for all chemicals can be written to file as shareable input data (CSV), statistical results tables (CSV), rank plots (PNG), and customized arrangements of ToxPi profile arrays (PDF, Portable Network Graphics (PNG), Scalable Vector Graphics (SVG))
Summary
We detail the implementation of a new graphical user interface for ToxPi (Toxicological Prioritization Index) that provides interactive visualization, analysis, reporting, and portability. The interface is deployed as a stand-alone, platform-independent Java application, with a modular design to accommodate inclusion of future analytics. The new ToxPi interface introduces several features, from flexible data import formats (including legacy formats that permit backward compatibility) to similarity-based clustering to options for high-resolution graphical output
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