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Abstract
Intradermal skin tests, consisting of viable Toxoplasma gondii organisms, were injected into normal guinea pigs and guinea pigs chronically infected with Toxoplasma. Subsequent gross and histological observations of the reaction sites were made. Whereas erythema and induration were present at the reaction site in normal animals, these criteria of delayed hypersensitivity (DH) were markedly increased in Toxoplasma-infected guinea pigs. Histologically, rapid mononuclear cell infiltration occurred early in the development of DH in immune animals, suggesting the appearance of a classical tuberculin DH reaction. The presence of numerous intracellular Toxoplasma organisms in the reaction sites of normal guinea pigs contrasted sharply with the inability to demonstrate any parasites at the site of infection in Toxoplasma-immune animals.
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