Abstract
Toxin-Antitoxin Systems - A New Player in Morphological Transformation of Antibiotic-Exposed Helicobacter pylori?
Highlights
The recently published original article by Mortaji et al (2020) characterized for the first time the function of a type I toxin-antitoxin (TA) system in the gastric pathogen Helicobacter pylori
Toxin-Antitoxin Systems in H. pylori accompanied by the transition of morphology from spiral to coccoidal (Mortaji et al, 2020)
It is worth paying attention to the results presented by many research teams that have shown that bactericidal antibiotics, unlike bacteriostatic ones, stimulate the formation of oxygen free radicals and oxidative stress in bacterial cells, regardless of their target site (Kohanski et al, 2007; Brynildsen et al, 2013; Dwyer et al, 2014; Belenky et al, 2015; Lobritz et al, 2015; Li et al, 2017)
Summary
The recently published original article by Mortaji et al (2020) characterized for the first time the function of a type I toxin-antitoxin (TA) system in the gastric pathogen Helicobacter pylori. It was found that the high expression of an AapA1 toxin, which is part of this system, causes a drastic decrease in the amount of culturable H. pylori cells and their transformation from a spiral to a coccoid morphotype.
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