Abstract
86Rb+ efflux was measured on polarized Madin-Darby canine kidney cells under A23187 or ATP stimulation. This efflux, inhibited by barium, Leiurus quinquestriatus hebraeus venom and charybdotoxin was attributed to the stimulation of Ca++-activated maxi K+ channels. Snake venom from Dendroaspis polylepis did not alter the stimulation as well as did apamine. ATP was effective on both the apical and basolateral membranes and the Ca++-activated maxi K+ channels were predominently found on the basolateral membrane. This study presents the physiological evidence that dendrotoxin is ineffective on the epithelial Ca++-activated maxi K+ channel present in MDCK cells.
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