Abstract
The results of the acute toxicity studies in mice and rats and subacute toxicity studies in rats, dogs, and monkeys of hydroxypyridinethione and its sodium salt have been presented. With repeated daily dosing the dog exhibited, in addition to sporadic emesis, lacrimation, and conjunctival erythema, a specific optic sensitivity involving a prolonged dilatation of the pupil as well as a concomitant loss of pupillary response to light and apparent blindness. Continuation of dosing, after the full onset of these signs, resulted in irreversible changes. Nutritional deficiencies appeared to enhance the dogs' susceptibility to these ocular manifestations. Rats and monkeys, although demonstrating transient signs of toxicity, did not exhibit these marked ocular alterations.
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