Abstract
The paper presents basic concepts of toxicological problems under human containment in a closed hermetic hyperbaric volume basing on the literature data and our own long-term scientific and practical experience aimed at diving and diving medicine, development and testing of the decompression chambers. The paper describes the following essentials of the problem: gaseous atmospheric composition in closed hermetic volumes, evolution of exogenous gases in human organism under lowering in the chamber, evolving hazardous gaseous substances (HGS) in the closed volume, design average daily rate of HGS evolving, effect of conditions on HGS evolving, their maximum permissible concentrations, methods of СО2 and HGS removal in the chambers, and regulatory requirements. It is shown that the most of the modern existing chambers do not meet the regulatory requirements that may result in negative effects on human health. The ways to except the cases of human intoxication in the decompression chambers and systems are offered in the paper.
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