Abstract
Within the frame of an international collaborative study, the synthesis of gram amounts of 2-alkylcyclobutanones (2-ACBs) was successfully carried out. The analysis of the amount of these radiolytic compounds in various irradiated foods made it possible to clearly highlight the linear relation between the formation of 2-ACBs and the absorbed radiation dose even for very high absorbed doses. Concerning the toxic potential, it was shown that the 2-ACBs have cyto- and geno-toxic properties under precise experimental (in vitro) conditions, that they inhibit bacterial growth and that these compounds have a promoter effect (in vivo studies) for the development of tumors in the colon of rats. The 2-ACBs thus present some potential risks. Whether they exert their toxic properties in irradiated foods, and pose a risk for the consumption of irradiated foods can at present not be quantified, due to the lack of necessary studies on their metabolism and interaction with other food constituents.
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