TOXICOLOGICAL STUDY OF MUGDHA RASA, AN AYURVEDIC FORMULATION

Abstract

Mugdha Rasa is one type of Kharaliya Rasayana and comes under Nirgandha, Niragni Murchana of Parada. Parada and Khatika are the main ingredients of Mugdha Rasa. This investigation is an attempt to perform toxicological study of Mugdha Rasa. Acute toxicological study and sub-acute toxicological study were carried out as per OECD guideline 425 and 407 respectively. Oral acute toxicity study was carried out at the limit dose of 2000 mg/ kg orally in Swiss albino mice. Sub- acute toxicity study of Mugdha Rasa was carried out in Albino rats and it was administered at therapeutic equivalent dose (TED), TED ×2 and TED×5. No signs of toxicity and mortality were observed Mugdha Rasa in acute toxicity study. So, LD50 of Mugdha Rasa is greater than 2000 mg/kg body weight and Mugdha Rasa can be considered assafe on acute exposure. The data generated during sub-acute toxicity study are indicated that it is not a hazardous substance for sub-acute administration at TED dose level. Higher dose levels show mild changes in parameters.