Abstract
We have already recognized that Zn-DTPA (diethylenetriaminepentaacetic acid) is less toxic than Ca-DTPA when they are administered orally to rats. In this study, in order to estimate exactly the safety of Zn-DTPA by the oral administration in humans, by evaluating the degrees of damages in the different animal species between beagle dogs and rats, we examined the toxicity of Zn-DTPA in beagle dogs according to the same methods as the rat, and then the results were compared with those in the rat. Zn-DTPA was administered daily to beagle dogs for 1 month, with the doses of 30, 150, 300μmol/kg body weight. The decreases of body weight, hemorrhage and congestion, and vascular expansion of the lamina propria mucosa and under the serious membrane of the small intestine, and the slight damages of kidney were observed. These changes were similar to those in rats at the same dose.As a result, it is recognized that there are almost no differences on the Zn-DTPA toxicity between dogs and rats, therefore the safety of orally administered Zn-DTPA in humans might be estimated from the results obtained in the animal experiments without considering the remarkable species differences.
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