Abstract
Using whole body- and micro-radioautography it was found that radio-activity was specifically retained for more than a month following an i.v. injection of 14C-chloroquine in the retinal pigment epithelium of pigmented rats and guinea-pigs, but not in that of albino animals. By a long term oral administration of chloroquine the intensive accumulation of melanin granules in the pigment epithelium and also in the choroid of the pigmented guinea-pig was observed. Using synthetic melanin, chloroquine was found to be adsorbed by melanin in two modes; one operates in low chloroquine concentrations and is extremely strong and independent to pH, and the other operates in higher chloroquine concentrations and is pH-dependent and chloroquine can be released by washing.
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