Abstract
The toxicity of floctafenine, a nonnarcotic agent with analgesic properties, was investigated in mice, rats, rabbits, and dogs after single-dose oral or parenteral administration, and in rats and dogs after repeated oral administration for periods of 6 months. At high doses, floctafenin induced gastric lesions, particularly in dogs. It has a safety margin between active dose and toxic dose much wider than that of aspirin or indomethacin. High doses administered to pregnant mice, rats, and rabbits had some embryotoxic, but no teratogenic activity.
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