Abstract
Chondrokola Rosh (CKR) is a traditional metallic Ayurvedic preparation widely used by the rural and ethnic people of Bangladesh in dysuria. It is a preparation of various roasted metals (Hg and Cu), non-metal (sulphur and Mica) and medicinal herbs. Considering the controversy over the risk of toxic heavy metals in Ayurvedic herbo-mineral preparations, toxicological parameters on liver functions were investigated. A single dose of 100mg/kg body weight of the preparation was administered orally to the rats of both sexes for ninety days. In this evaluation a statistically significant (p<0.001) increase of serum albumin levels in male (17%) and female (15%) rat groups were observed. On the other hand, the plasma bilirubin level was decreased 50% and 28% respectively in both rats groups. But no remarkable differences were observed in plasma protein, sGPT, sGOT and ALP activities from their corresponding control values. This study showed that CKR had no remarkable toxic effect on liver of the animals despite the presence of traces of transformed heavy metals.
Highlights
Rasa shastra (Vedic chemistry), branch of Ayurveda, describes the use of metals, gems, minerals and even poisons for manufacturing special formulations to combat chronic and difficult diseases
Chondrokola Rosh is included in the Bangladesh National Formulary of Ayurvedic Medicine (BNFAM) 1992 (Approved by the Government of Bangladesh vide Ministry of Health and Family Welfare Memo No Health-1/Unani-2/89/ (Part1) 116 dated 3-6-1991)
Chondrokola Rosh (CKR), a traditional Ayurvedic herbo-mineral preparation widely used by the rural people of Bangladesh in dysuria
Summary
Rasa shastra (Vedic chemistry), branch of Ayurveda, describes the use of metals, gems, minerals and even poisons for manufacturing special formulations to combat chronic and difficult diseases. Chondrokola Rosh (CKR) is one of unique metallic-herbal Ayurvedic preparations used as alternative medicines among Bangladeshi peoples In this preparation various roasted metals (bhasma) are used with other medicinal plants. It is believed that heavy toxic metals such as mercury used in traditional medicine act as a catalyst, which stimulate activity by their presence in the intestines without ever reaching the blood stream (Kumar et al, 2006). It is believed that heavy toxic metals such as mercury used in traditional medicine system act as a catalyzer, which stimulate activity by their presence in the intestines without ever reaching the blood stream ((Kumar et al, 2006). Considering the recent controversy over the risk of toxic heavy metals in Ayurvedic herbo-mineral preparations, the present study deals with the toxicological evaluation of Chondrokola Rosh (CKR), a traditional Ayurvedic preparation, on liver functions tests using male and female rats after chronic administration
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