Toxicological Effect of Prolonged Coca-Cola and Bullet Soft Drinks Consumption on Male Hormonal and Testicular Oxidative Profile in Wistar Rats

Abstract

This study examines the effects of prolonged consumption of soft and bullet drinks on different sex hormones i.e. luteinizing hormones (LH), Follicle Stimulating Hormone (FSH), Testosterone (T), testicular antioxidative parameters ie Malondialdehyde (MDA), superoxide dismutase (SOD)and the histopathological effects of soft drinks consumption on the testis. Thirty five (35) male wistar rats were employed in this study for seven weeks.Group1 (control) was giving normal feeds and water ad libitum, group2 was administered 1.2ml coca cola drinks,Group3 double dose (2.4ml) coca cola drinks,Gruop4 (0.6ml) bullet drinks while 1.2ml sugar solution was given to group5 including normal feeds and water ad libitum.The results from this study shows significant decrease in superoxide dismutase mean values among the test groups compared with control while in Malondialdehyde there was an increased significantly in group4 administered bullet drinks (13.60µg/mg), group2 mean values administered 1.2ml coca cola drinks was (7.50 µg/mg), group3 administered double dose of 2.4ml Coca Cola drinks daily was (6.60µg/mg) while gruop5 mean values administered 1.2ml sugar solution daily was (5.00 µg/mg) compared with the control group of (2.60 µg/mg) mean significant values of <0.05. There was a significant increase in the mean reproductive hormones mean values among the test groups compared with the control group. except the testosterone mean value in group5 administered sugar solution that has lower value than the control group. Findings from this study have shown the toxicological adverse effect of prolonged consumption of coca cola and bullet soft drinks on testicular pathophysiology and significant increase in male reproductive hormones signaling testicular damaged which can result in infertility among males.