Abstract
A battery of studies was conducted to examine the toxicological potential of dihydroberberine (DHBBR), a derivative of berberine (BBR). The genotoxicity studies conducted on DHBBR, including the bacterial reverse mutation test, the mouse lymphoma assay, and the in vivo micronucleus test, showed that DHBBR is non-mutagenic and non-clastogenic. An acute oral toxicity study revealed that the LD50 of DHBBR in female Sprague Dawley rats was greater than 2000mg/kg bw. In a 14-day oral dose range finding study, the maximum tolerated dose was the high dose, 120mg/kgbw/day. Based on a 90-day oral toxicity study in male and female Sprague Dawley rats, it was concluded that the NOAEL for DHBBR is 100mg/kgbw/day, the highest dose tested.
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Schedule a callMore From: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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