Abstract
Silicates are ubiquitous in nature and exhibit diverse speciation and unique physiochemical properties. Though abundant in diet, their biological role in animals is not clearly understood. In our previous study, we showed that a unique soluble species of silicate [Na8.2Si4.4H9.7O17.6] modulated stress response signaling pathways in vivo and may have implications in human health. Here we present results from toxicological and cancer chemopreventive evaluation of Na8.2Si4.4H9.7O17.6. Results suggest LD50 >;5000 mg/kg for acute oral toxicity of silicates in Sprague‐Dawley rats. Undiluted silicate was found to be non‐corrosive in rabbit skin corrosion study. A statistically significant reduction in fibroblast, platelet‐derived and vascular endothelial growth factor induced angiogenesis was observed in the chick embryo chorioallantoic membrane model at >;18.8 nM. A significant reduction in the size of the NM2C5 tumors was observed in vitro in the three‐dimensional tumor microenvironment model at a dosage of >;18.8 nM. At a dosage of >; 7.5 mM the silicate also decreased the tumor development and metastasis of LOX‐GFP human melanoma in Male NCr nude mice by ~15%. Our results suggest that soluble silicates may have potential cancer‐chemopreventive effects and merits further detailed investigation to understand mechanism of action.
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