TOXICOLOGICAL AND BIOLOGICAL INDICES OF THE HOUSE FLY, MUSCA DOMESTICA AFTER CSI'S TREATMENTS: LUFENURON, FLUFENOXURON AND HEXAFLUMURON

Abstract

The house fly, Musca domestica transmits many diseases to humans, so that controlling it withoutside effects on human health is extremely important. Therefore, the current study aimed tocompare the toxicity of tested chitin synthesis inhibitors (CSIs) lufenuron, flufenoxron, and hexflumuronagainst 3rd instar larvae of the house fly, and to assess the lethality effects by serialconcentrations (1000, 500, 250 & 125ppm) of each tested compound on the developmental parametersand growth indices of the immature stages of M. domestica. The least toxicity valuesof sub-lethal concentrations (LC25, LC50 & LC75) displayed for lufenuron (158.23, 332.46 &698.56, respectively). Also, hexaflumuron scored (64.06ppm at LC25), followed by flufenoxuron(140.95 & 283.62ppm at LC50 & LC75, respectively). Flufenoxuron was the most toxic, followedby hexaflumuron and lufenuron. CSIs showed a toxic efficiency on 3rd instar larvae of M. domesticaby decreasing developmental and growth indices rates at higher concentrations of eachone. Flufenoxuron exhibited a marked significant decrease in larval development and growth indexrates (15.50 & 2.71% at 1000ppm, respectively), highest water loss (69.79%) compared tohexaflumuron and lufenuron. Flufenoxuron was the most toxic one against pupae as compared toothers, it prolonged pupal duration (14.71day) and induced pupal water loss (53.77%), its pupation,developmental and weight rate reduced (17.5 & 6.8%, & 53.77mg respectively). But, growthindex did not cause mortality with the highest concentration. Adult emergence displayednon-adult emergence and a high percentage of the malformation rate at 1000ppm when treatedwith flufenoxuron compared to other compounds.