Abstract
The acute LD 50's for a highly purified preparation of paralytic shellfish poison in mice were determined for the oral (263 μg/kg), intraperitoneal (10.0 μg/kg), and intravenous (3.4 μg/kg) routes. Female mice were more susceptible than males to lethal doses of the poison. Increases of pH of the injection medium or the addition of sodium ions reduced the intraperitoneal toxicity. These two effects were not additive and the sodium effect appeared to be the stronger. The sodium ion did not influence the oral or intravenous toxicity. The use of the median death time as a criterion of toxicity is not reliable at pH levels above 4.0 or in the presence of sodium ions above 0.1 M. However, under the specified conditions of the bioassay procedure of the Association of Official Agricultural Chemists, satisfactory results are obtained.
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