Abstract
The basic knowledges for toxicologic pathology of the nasal cavity in rat and mouse, including methods of preparation of their tissue specimens, anatomical and histological features, spontaneous lesions, and toxic injuries induced by chemical substances are described. In our laboratory, the following three frontal _??_ection_??_ are examined regularly: i.e. at the level of the posterior edge of upper incisor teeth (level I), at the incisive papilla (level II), and at the level of the anterior edge of upper molar teeth (level III). The _??_pontaneous lesions found in F344 rat are rhinitis, eosinophilic change of epithelial cells, accumulation of foreign bodies in the nasal cavity, submucosal deposition of calcium, venous thrombosis, and respiratory epithelium metaplasia of the olfactory epithelium. Those seen in BDF I mouse are rhinitis. eosinophilic change of epithelial cells, and respiratory epithelium metaplasia of the olfactory epithelium and nasal glands. The toxic injuries of the nasal cavity caused by chemical compounds including fumigant, formaldehyde, vinyl chloride monomer, dimethylnitrosamine, and glycol ether solvent are demonstrated.
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