Abstract
The distribution and elimination of dicamba (3,6-dichloro-2-methoxy benzoic acid) and another isomer present in dicamba formulation (3,5-dichloro-2-methoxy benzoic acid) were studied in rats following single intravenous injections. Concentrations of dicamba and the isomer were measured at various times in whole blood by EC-GLC after extraction and derivatization with diazomethane. The isomer had different toxicokinetic parameters compared to dicamba. The elimination of dicamba from the blood was rapid with a biological half-life of 0.64 hr (following 100 mg/kg iv dose) while the elimination of the isomer from the blood was much slower with a biological half-life of 16.5 hr (following 20 mg/kg iv dose). However, upon combined dosing of the two compounds the elimination rate constant of dicamba significantly decreased. The isomer had a greater degree of binding to blood serum proteins than dicamba.
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