Toxicity Prediction of meso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl] porphyrin and meso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl],10,20-diphenyl porphyrin

Abstract

Porphyrin and its derivatives are widely investigated for cancer therapy because of their high selectivity to cancer cells. By labeling gamma and beta emitting-radionuclides to a porphyrin which selectively binds to the cancer tissue will produce a safe and potential radiopharmaceutical. The present study aims to predict the toxicity of meso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl]-porphyrin (D3,4BCPP) andmeso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl],10,20-diphenylporphyrin (D3,4BCPDPP) as well as their complexes with Rhenium (Re).Toxicity prediction using ADMET PredictorTM showed that D3,4BCPP has an acute toxicity in rat; D3,4BCPDPP has an acute toxicity in rat and hepatotoxic; Re-D3,4BCPP has an acute toxicity in rat, hepatotoxic, and likely carcinogenic in rat in which requiring microsomal activation mechanism; and Re-D3,4BCPDPP has an acute toxicity in rat and hepatotoxic.