Abstract
Toxicity of four novel Polyhedral Oligomeric Silsesquioxane (POSS) particles used in anti-cancer drug delivery Abdulmajeed Almutary, Barbara Sanderson
Highlights
Chemotherapy is necessary for the treatment of most solid tumours; adverse side effects often limit its benefits and impact on the patients quality of life (Nowak et al, 2003; Sutradhar and Amin, 2014)
The SiO2-sulfobetaine methacrylate (SBMA) nanoparticles did not decrease the mitochondrial activity of Caco-2 or HaCaT cell lines using MTT assays; the lactate dehydrogenase (LDH) leakage increased and relative cell number decreased at 2.00 mg/mL and was clearly observed after the particles were exposed to ultraviolet light (UV) light
In summary, thiolated SiO2 nanoparticles produced via a modified Stöber process were coated with a novel biocompatible zwitterionic sulfobetaine methacrylate via thiol-ene addition
Summary
Chemotherapy is necessary for the treatment of most solid tumours; adverse side effects often limit its benefits and impact on the patients quality of life (Nowak et al, 2003; Sutradhar and Amin, 2014). Tumours commonly have poor lymphatic drainage, which can reduce the removal of NPs (Maeda et al, 2000) This phenomenon is known as enhanced permeability and retention (EPR) (Canelas et al, 2009; Aliabadi et al, 2008; Matsumura and Maeda, 1986; Sutradhar and Amin, 2014). Some of surface coatings can prevent nanoparticle opsonization and aggregation, improve cellular uptake, increase wettability, and affect degradation rates (Khung and Narducci, 2015). This include polySBMA (sulfobetaine methacrylate), PEG, dextran, chitosan, pullulan, sodium oleate, dodecylamine, polysorbate 80, poloxamer 188, polyvinyl alcohol, poly-2- methyl-2-oxazoline, polyvinylpyrrolidone, and α-tocopherol PEG-1000 succinate (Izquierdo-Barba et al, 2016; Liu et al, 2014)
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