Abstract
The toxicity of tetrabromobisphenol‐A (TBBPA), which is a brominated flame retardant and used in large quantities, was investigated. The threshold for the decrease of body weight was from 0.3 to 3.0 mg/kg/day, and the weight ratio of kidney to body increased from 10 mg/kg/day. The hematocrit value and clotting time decreased, and the cholesterol concentration, blood urea nitrogen (BUN) concentration and choline esterase activity increased. Hemolysis occurred from low concentration (0.5 mg/L) and decreased by metabolization with hepatic microsomal enzyme system. When 500 mg/kg of TBBPA was administrated, TBBPA concentration increased rapidly, but decreased after 4 hr and remained still at 20 hr.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
