Toxicity of sodium cyanurate

Abstract

Sodium cyanurate fed to rats for 20 weeks and to dogs for 6 months was without evident adverse effects at a dietary concentration of 0.8%. Rats fed 8% of sodium cyanurate in the diet for 20 weeks showed consistent and characteristic histologic changes in the kidneys, consisting of dilatation of the distal collecting tubules and ducts of Bellini with focal areas of epithelial proliferation. Similar renal changes were observed in dogs fed 8% of sodium cyanurate in the diet for 16–24 months. Five milliliters of an 0.8% or 8% aqueous suspension of sodium cyanurate applied daily, 5 days/week, to the skin of rabbits for 3 months caused no adverse effects at the lower concentration. At the higher concentration, kidney changes similar to, but less marked than, those described in the rats and dogs were noted. No skin irritation was caused by either concentration. No eye irritation was observed in rabbits receiving 0.1 ml daily, 5 days/week, of an 8% aqueous suspension of sodium cyanurate instilled into one eye over a period of 3 months.