Abstract
The toxicity to ducklings and rats of a strain of Penicillium italicum isolated from an orange is described. Apart from a reduction in live-weight gain, feeding P. italicum culture material to ducklings at a dietary level of 50% (w/w) had no apparent detrimental effect over a period of 14 days. When the culture material was fed to rats at a dietary level of 8 or 32% (w/w) five out of six rats given the higher dose level died. The mean time to death was 78 days. A prominent cirrhosis of the liver was the predominant pathological change. This cirrhosis was characterized histologically by pseudolobulation, modular hyperplasia, scant bile-duct proliferation and the presence of various numbers of anaplastic cells.
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