Abstract
<h3>To the Editor:</h3> —In a communication toThe Journal, September 3, Dr. V. W. Jensen reported a reaction after the subcutaneous and submucous injection of nupercaine prior to a hemorrhoidectomy. The reaction consisted of dizziness, nausea, vomiting, loss of bladder and rectal control and unconsciousness. The reaction was not fatal. Dr. Jensen states that he used from 5 to 6 cc. of a 1 per cent nupercaine solution. Although this may seem like a very small dose, it is in reality a very large dose. The regular concentration of nupercaine that is used for subcutaneous injection is a 1:1,000 solution. The amount of nupercaine used in the case reported was between 50 and 60 mg., which would be as much as from 50 to 60 cc. of a 1: 1,000 solution. I think this reaction can be attributed to an overdosage of the drug. When used in the 1: 1,000
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